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1. Regarding two compartment pharmacokinetics:
a) a drug is always removed from the peripheral compartment
b) the central compartment is blood volume
c) a drug with a high volume of distribution is likely to be lipophillic
d) a drug can have a short duration of action while being eliminated very slowly
e) most anaesthetic drugs are modelled well with a two-compartment model
2. Desflurane:
a) is a fluorinated methylisopropyl ether
b) boils at 23 degrees C
c) is safe to use in patients with malignant hyperpyrexia
d) stimulates the sympathetic system when inspired concentration is suddenly increased
e) prolongs the duration of muscle relaxants
3. Regarding the use of suxamethonium:
a) bradycardia is a complication
b) phase II block occurs more commonly with neonates
c) prolonged duration of action may be seen in around one patient in 40
d) can raise the serum potassium by 0.5 mmol/ L
e) dose required is lower in small children
4. Concerning electroencephalography (EEG):
a) voltages are in the range of 10-100 millivolts
b) spontaneous EEG activity is lost when the body temperature drops below 25 degrees C
c) b waves are enhanced by sedatives
d) d waves only occur in brain injury
e) q waves occur at a frequency of 4-7 Hz
5. Action potentials:
a) are all or none signals of about 100 mV in amplitude
b) are generated by leakage of K+ down their concentration gradient
c) are normally conducted antidromically
d) summate at high frequencies
e) depend on the size of the stimulus
6. Conduction velocity of a nerve impulse:
a) is greater in C fibres than in group A fibres
b) is greater in large diameter nerve fibres
c) is greater in unmyelinated nerve fibres because of saltatory conduction
d) can be as fast as 120 m/s in human nerve fibres
e) is decreased in hypothermia
7. Regarding drug metabolism by cytochrome P450 isoenzymes:
a) cytochrome P450 makes up 1% of total liver proteins
b) the most important enzyme is CYP3A4
c) the system is responsible for most of the reductive metabolism in humans
d) volatile anaesthetics are metabolised by CYP2E1
e) some isoenzymes are inhibited strongly by erythromycin
8. Atropine:
a) may cause bradycardia
b) dilates the pupil in premedicant dose
c) has a shorter duration of action than glycopyrrolate
d) increases the physiological dead space
e) has both muscarinic and nicotinic effects
9. In the pulmonary circulation:
a) capillary hydrostatic pressure is about 25 mmHg
b) 50% of the cardiac output goes to the pulmonary circulation in the foetus
c) angiotensin is broken down
d) bradykinin is inactivated
e) hypoxia causes vasoconstriction
10. Regarding local anaesthetic agents (LA):
a) the potency of LAs is proportional to their lipid solubility
b) the duration of action is dependent on protein binding
c) agents with low pKa have a faster onset of action
d) all local anaesthetics are vasodilators
e) the depth of local anaesthetic block is increased by increasing the dose
11. Cisatracurium besylate:
a) is a mixture of three stereoisomers
b) in equipotent doses has a similar duration of action to vecuronium
c) is less potent than atracurium
d) undergoes more Hoffmans degradation than atracurium
e) in equipotent doses has a similar onset time to atracurium
12. If an electric current is fed through the body:
a) risk of injury is largely dependent upon the current flow
b) antistatic shoes provide good protection due to their high resistance
c) high frequencies are more dangerous than low frequencies
d) ventricular fibrillation occurs at a lower current in patients with dysrhythmias
e) a tingling sensation is felt at a current strength of 1 mA
13. The countercurrent concentrating mechanism in the kidney:
a) depends on active transport of sodium and chloride out of the ascending loop of Henle
b) allows an osmolality of 1200 mosmoles/kg in distal tubules
c) occurs predominantly in the cortical nephrons
d) relies on the free movement of water and electrolytes across the walls of the vasa recta
e) depends on a low concentration of urea in the medullary interstitium
14. The adverse effects of NSAIDs on the kidney:
a) are reversible in normal kidneys
b) are not dose related
c) are mediated by inhibition of PGI2 synthesis
d) may cause acute interstitial nephritis
e) are counteracted by the use of ACE inhibitors
15. The following trigger the secretion of antidiuretic hormone from the posterior hypothalamus:
a) a 5% reduction in extracellular fluid
b) chronic renal failure
c) anxiety
d) supine position
e) head injury
16. Concerning the measurement of oxygen:
a) an oxygen electrode should be calibrated at zero and in room air
b) oxygen tension in a liquid can be measured with a Clark electrode
c) a polarographic electrode can be used in vivo
d) oxygen measurement in a gas mixture makes use of the magnetic property of oxygen
e) a fuel cell has a rapid response to change in oxygen concentration
17. Drug clearance:
a) is the amount of drug removed from plasma in unit time
b) is proportional to half-life
c) is low in lipid-soluble drugs
d) occurs only in the liver and kidney
e) is calculated by dividing the dose of drug given by area under plasma concentration-time curve
18. The volume of distribution of a drug:
a) is low if the drug is highly protein bound
b) can be calculated by multiplying half-life by natural logarithm of 2
c) is relatively low for muscle relaxants
d) is proportional to half life
e) is dependent on the elimination rate constant
19. Concerning composition of body fluids:
a) plasma constitutes a quarter of extracellular fluid (ECF) volume
b) ECF volume may be grossly depleted in intestinal obstruction
c) the protein content of interstitial fluid is higher compared with intracellular fluid (ICF) and plasma
d) the ratio of ECF/ICF volume is smaller in infants and children
e) the normal osmolality of plasma is 280 mosmoles/kg
20. Aldosterone causes:
a) a decrease in urine sodium concentration
b) weight gain
c) decreased serum chloride level
d) increased extracellular fluid volume
e) increased K+ excretion
21. The following antibiotics have good activity against anaerobic bacteria:
a) vancomycin
b) aztreonam
c) metronidazole
d) imipenem
e) trimethoprim
22. Flumazenil:
a) may induce panic attacks in susceptible patients
b) has anticonvulsant activity in patients with epilepsy
c) has a long duration of action
d) may cause nausea and vomiting
e) has inverse agonist action at benzodiazepine receptors
23. Concerning the blood brain barrier (BBB):
a) it is virtually impermeable to ions and proteins
b) it breaks down around brain infarcts
c) a rise in serum albumin by 20 g/L will draw more H2O across the BBB than a rise in serum Na+ by 5 mmol/L
d) when damaged, cytotoxic brain oedema results
e) mannitol crosses the BBB easily
24. Osmolality:
a) is the number of osmotically active particles per litre of solvent
b) of urine is similar to that of plasma in chronic renal failure
c) may be estimated by formula 2X(Na+K) + Blood sug + BUN
d) is measured by amount of depression of the freezing point
e) is a part of colloid oncotic pressure
25. ABO compatibility is essential for transfusion of:
a) SAGM blood
b) haemoglobin solutions
c) cryoprecipitates
d) FFP
e) platelets
26. The following increase during pregnancy:
a) plasma volume
b) fibrinogen
c) gastric emptying time
d) glucose tolerance
e) arterial PaCO2
27. Carbon monoxide:
a) binds to haemoglobin with 100 times the affinity of oxygen
b) results in the oxyhaemoglobin curve shifting to the left
c) poisoning can be reliably detected by pulse oximetry
d) levels in normal non-smokers is 10-15%
e) concentration in circle is increased during desflurane anaesthesia
28. Resting potential across the nerve membrane:
a) depends largely on the ratio of K+ inside and outside the cell
b) is positive inside with respect to outside
c) is of the order of 0.06 volt
d) decreases in magnitude during prolonged hypoxia
e) is greater the larger the diameter of the nerve fibre
29. Activation of NMDA receptors:
a) is important in learning and memory
b) can result in neuronal damage
c) is involved in the development of opioid tolerance
d) causes opening of the chloride channel
e) may increase the intensity of pain
30. Bacteria develop resistance to antibiotics:
a) by changing permeability of porin channels in cell wall
b) by producing enzymes to inactivate antibiotics
c) by altering target sites (DNA gyrase and topoisomerase) for antibiotics
d) by active extrusion of antibiotic once it enter the cell
e) easily in presence of necrotic tissue
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a) a drug is always removed from the peripheral compartment
b) the central compartment is blood volume
c) a drug with a high volume of distribution is likely to be lipophillic
d) a drug can have a short duration of action while being eliminated very slowly
e) most anaesthetic drugs are modelled well with a two-compartment model
2. Desflurane:
a) is a fluorinated methylisopropyl ether
b) boils at 23 degrees C
c) is safe to use in patients with malignant hyperpyrexia
d) stimulates the sympathetic system when inspired concentration is suddenly increased
e) prolongs the duration of muscle relaxants
3. Regarding the use of suxamethonium:
a) bradycardia is a complication
b) phase II block occurs more commonly with neonates
c) prolonged duration of action may be seen in around one patient in 40
d) can raise the serum potassium by 0.5 mmol/ L
e) dose required is lower in small children
4. Concerning electroencephalography (EEG):
a) voltages are in the range of 10-100 millivolts
b) spontaneous EEG activity is lost when the body temperature drops below 25 degrees C
c) b waves are enhanced by sedatives
d) d waves only occur in brain injury
e) q waves occur at a frequency of 4-7 Hz
5. Action potentials:
a) are all or none signals of about 100 mV in amplitude
b) are generated by leakage of K+ down their concentration gradient
c) are normally conducted antidromically
d) summate at high frequencies
e) depend on the size of the stimulus
6. Conduction velocity of a nerve impulse:
a) is greater in C fibres than in group A fibres
b) is greater in large diameter nerve fibres
c) is greater in unmyelinated nerve fibres because of saltatory conduction
d) can be as fast as 120 m/s in human nerve fibres
e) is decreased in hypothermia
7. Regarding drug metabolism by cytochrome P450 isoenzymes:
a) cytochrome P450 makes up 1% of total liver proteins
b) the most important enzyme is CYP3A4
c) the system is responsible for most of the reductive metabolism in humans
d) volatile anaesthetics are metabolised by CYP2E1
e) some isoenzymes are inhibited strongly by erythromycin
8. Atropine:
a) may cause bradycardia
b) dilates the pupil in premedicant dose
c) has a shorter duration of action than glycopyrrolate
d) increases the physiological dead space
e) has both muscarinic and nicotinic effects
9. In the pulmonary circulation:
a) capillary hydrostatic pressure is about 25 mmHg
b) 50% of the cardiac output goes to the pulmonary circulation in the foetus
c) angiotensin is broken down
d) bradykinin is inactivated
e) hypoxia causes vasoconstriction
10. Regarding local anaesthetic agents (LA):
a) the potency of LAs is proportional to their lipid solubility
b) the duration of action is dependent on protein binding
c) agents with low pKa have a faster onset of action
d) all local anaesthetics are vasodilators
e) the depth of local anaesthetic block is increased by increasing the dose
11. Cisatracurium besylate:
a) is a mixture of three stereoisomers
b) in equipotent doses has a similar duration of action to vecuronium
c) is less potent than atracurium
d) undergoes more Hoffmans degradation than atracurium
e) in equipotent doses has a similar onset time to atracurium
12. If an electric current is fed through the body:
a) risk of injury is largely dependent upon the current flow
b) antistatic shoes provide good protection due to their high resistance
c) high frequencies are more dangerous than low frequencies
d) ventricular fibrillation occurs at a lower current in patients with dysrhythmias
e) a tingling sensation is felt at a current strength of 1 mA
13. The countercurrent concentrating mechanism in the kidney:
a) depends on active transport of sodium and chloride out of the ascending loop of Henle
b) allows an osmolality of 1200 mosmoles/kg in distal tubules
c) occurs predominantly in the cortical nephrons
d) relies on the free movement of water and electrolytes across the walls of the vasa recta
e) depends on a low concentration of urea in the medullary interstitium
14. The adverse effects of NSAIDs on the kidney:
a) are reversible in normal kidneys
b) are not dose related
c) are mediated by inhibition of PGI2 synthesis
d) may cause acute interstitial nephritis
e) are counteracted by the use of ACE inhibitors
15. The following trigger the secretion of antidiuretic hormone from the posterior hypothalamus:
a) a 5% reduction in extracellular fluid
b) chronic renal failure
c) anxiety
d) supine position
e) head injury
16. Concerning the measurement of oxygen:
a) an oxygen electrode should be calibrated at zero and in room air
b) oxygen tension in a liquid can be measured with a Clark electrode
c) a polarographic electrode can be used in vivo
d) oxygen measurement in a gas mixture makes use of the magnetic property of oxygen
e) a fuel cell has a rapid response to change in oxygen concentration
17. Drug clearance:
a) is the amount of drug removed from plasma in unit time
b) is proportional to half-life
c) is low in lipid-soluble drugs
d) occurs only in the liver and kidney
e) is calculated by dividing the dose of drug given by area under plasma concentration-time curve
18. The volume of distribution of a drug:
a) is low if the drug is highly protein bound
b) can be calculated by multiplying half-life by natural logarithm of 2
c) is relatively low for muscle relaxants
d) is proportional to half life
e) is dependent on the elimination rate constant
19. Concerning composition of body fluids:
a) plasma constitutes a quarter of extracellular fluid (ECF) volume
b) ECF volume may be grossly depleted in intestinal obstruction
c) the protein content of interstitial fluid is higher compared with intracellular fluid (ICF) and plasma
d) the ratio of ECF/ICF volume is smaller in infants and children
e) the normal osmolality of plasma is 280 mosmoles/kg
20. Aldosterone causes:
a) a decrease in urine sodium concentration
b) weight gain
c) decreased serum chloride level
d) increased extracellular fluid volume
e) increased K+ excretion
21. The following antibiotics have good activity against anaerobic bacteria:
a) vancomycin
b) aztreonam
c) metronidazole
d) imipenem
e) trimethoprim
22. Flumazenil:
a) may induce panic attacks in susceptible patients
b) has anticonvulsant activity in patients with epilepsy
c) has a long duration of action
d) may cause nausea and vomiting
e) has inverse agonist action at benzodiazepine receptors
23. Concerning the blood brain barrier (BBB):
a) it is virtually impermeable to ions and proteins
b) it breaks down around brain infarcts
c) a rise in serum albumin by 20 g/L will draw more H2O across the BBB than a rise in serum Na+ by 5 mmol/L
d) when damaged, cytotoxic brain oedema results
e) mannitol crosses the BBB easily
24. Osmolality:
a) is the number of osmotically active particles per litre of solvent
b) of urine is similar to that of plasma in chronic renal failure
c) may be estimated by formula 2X(Na+K) + Blood sug + BUN
d) is measured by amount of depression of the freezing point
e) is a part of colloid oncotic pressure
25. ABO compatibility is essential for transfusion of:
a) SAGM blood
b) haemoglobin solutions
c) cryoprecipitates
d) FFP
e) platelets
26. The following increase during pregnancy:
a) plasma volume
b) fibrinogen
c) gastric emptying time
d) glucose tolerance
e) arterial PaCO2
27. Carbon monoxide:
a) binds to haemoglobin with 100 times the affinity of oxygen
b) results in the oxyhaemoglobin curve shifting to the left
c) poisoning can be reliably detected by pulse oximetry
d) levels in normal non-smokers is 10-15%
e) concentration in circle is increased during desflurane anaesthesia
28. Resting potential across the nerve membrane:
a) depends largely on the ratio of K+ inside and outside the cell
b) is positive inside with respect to outside
c) is of the order of 0.06 volt
d) decreases in magnitude during prolonged hypoxia
e) is greater the larger the diameter of the nerve fibre
29. Activation of NMDA receptors:
a) is important in learning and memory
b) can result in neuronal damage
c) is involved in the development of opioid tolerance
d) causes opening of the chloride channel
e) may increase the intensity of pain
30. Bacteria develop resistance to antibiotics:
a) by changing permeability of porin channels in cell wall
b) by producing enzymes to inactivate antibiotics
c) by altering target sites (DNA gyrase and topoisomerase) for antibiotics
d) by active extrusion of antibiotic once it enter the cell
e) easily in presence of necrotic tissue
ANSWERS
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