موضوع تخديري هام

شكرا للزميلة ZAINA22
the patients with active tuberculous focus & have ellctive surgery should be postponded until three successive negative AFB -sputum.
but a specific important points should be pay attension:

Check baseline renal and liver function in all patients. If normal, and not at high risk of adverse drug reaction, they do not need to be re-checked

Rifampicin (R) bactericidal. Single daily dose, well tolerated.
Increases hepatic microsomal enzymes; therefore increases clearance of hepatic metabolized drugs

Pyrazinamide (Z) bactericidal. Single daily dose. GI upset common. Major side-effect is hepatic toxicity.

TB drugs in patients with abnormal liver function tests
Chronic liver disease—regular monitoring of LFTs, weekly for first 2 weeks, then at 2 weekly intervals